High fat diets alter aerobic exercise and L-arginine effects in ischemia reperfusion induced renal injury in rats: gender related difference
محل انتشار: فصلنامه پزشکی هرمزگان، دوره: 21، شماره: 3
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 391
فایل این مقاله در 10 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_HMJ-21-3_005
تاریخ نمایه سازی: 27 مرداد 1397
چکیده مقاله:
Introduction: Renal ischemia reperfusion (I/R) caused kidney injury gender dependently.High fat diet (HFD) contributes the development of renal dysfunction. L-arginine (L-arg)and regular exercise are recognized to be protective in I/R and lipotoxicity. We comparedthe role of aerobic exercise and L-arg supplementation against renal I/R in male and femalerats fed with HFD.Methods: 54 adult male and female Wistar rats received standard control diet (control),HFD, HFD plus L-arg (HFD±L-arg) or HFD plus aerobic exercise (HFD±EX) for 8weeks. Then the animals were subjected to renal I/R by clamping renal vessels for periodof 45 min followed by 24 hour reperfusion.Results: The serum levels of blood urea nitrogen (BUN) and creatinine (Cr), and kidneytissue damage score (KTDS) were not significantly different between HFD and controlgroups in two genders. However, the serum level of nitrite and kidney tissue level ofmalondialdehyde (MDA) in HFD fed male rats increased significantly (P<0.05). Also,kidney weight (KW) had significant decrement in HFD groups in comparison with controlgroups in two genders (P<0.05). L-arg and aerobic exercise decreased the BUN levels andKTDS in male rats after renal I/R (P<0.05), but such observations were not seen in female.Conclusion: These results indicated that L-arg and aerobic exercise could amelioraterenal I/R induced kidney injury in HFD male rats but not in female.
کلیدواژه ها:
نویسندگان
Effatsadat Vafamand
Department of Physical Education and Sport Sciences, University of Mohaghegh Ardebili, Ardebil, Iran- Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Lotfali Bolboli
Department of Physical Education and Sport Sciences, University of Mohaghegh Ardebili, Ardebil, Iran
Hossein Jahani-Azizabadi
Department of Animal Science, University of Kurdistan, Sannandaj, Iran.
Ardeshir Talebi
Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran