Outcomes of Patients with COVID-۱۹ and Fungal Coinfections: A Systematic Review and Meta-Analysis Study
محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 19، شماره: 2
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 34
نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJP-19-2_001
تاریخ نمایه سازی: 19 اردیبهشت 1403
چکیده مقاله:
Background & Objective: Fungal co-infections increase the incidence and mortality of viral respiratory tract infections. This study systematically reviews and conducts a meta-analysis to evaluate the prevalence of COVID-۱۹ patients with fungal coinfections. The aim is to provide a concise overview of the impact of these infections on patient outcomes especially association with risk of mortality, informing future research and optimizing patient management strategies.Methods: To identify relevant studies on COVID-۱۹ patients, we conducted a systematic search of databases from the beginning of the year until July ۲۰۲۳, including fungal co-infections, mortality, and sequelae. Eligibility criteria were developed using the PICO framework, and data extraction was carried out separately by two authors using standard techniques. Statistical analysis was performed using the correlation model and differences between studies were evaluated using the I۲ test. R and RStudio were used for statistical analysis and visualization.Results: We initially identified ۶,۷۶۴ studies, and after checking for equivalence and consistency, ۴۱ studies were included in the final analysis. The overall COVID-۱۹ odds ratio for people who died from fungal infections was ۲.۶۵, indicating that patients infected with both COVID-۱۹ and fungal infections had a higher risk of death compared to patients with COVID-۱۹ alone. Specifically, COVID-۱۹-associated pulmonary aspergillosis (CAPA) has a higher odds ratio of ۳.۳۶, while COVID-۱۹-associated candidiasis (CAC) has an odds ratio of ۱.۸۴, and both are much more associated with death. However, coinfection of the fungus with other fungal species did not show a significant difference in the risk of mortality.Conclusion: This study identified CAPA and CAC as the most common infections acquired in healthcare settings. Fungal coinfections may be associated with an increased risk of death in COVID-۱۹ patients.
کلیدواژه ها:
نویسندگان
Mahsa Abdorahimi
Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran
Alireza Abdollahi
Department of Pathology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Sadegh Khodavaisy
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Research Center for Antibiotic Stewardship and Antimicrobial Resistance, Imam Khomeini Hospital Complex, Tehran, Iran
Haleh Sarrafnia
Faculty of Biological Sciences, Islamic Azad University, Tehran-North Branch, Tehran, Iran
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :