The Association between Dietary Acid Load and Non-Communicable Diseases: A Cohort Study in Shahrekord

Background and aim: It has recently been suggested that acid-base imbalances may play a role in some types of cardiovascular diseases and metabolic disorders. The aim of this study is to investigate the association between dietary acid load and common non-communicable diseases (NCDs). Methods: In this cross-sectional study, ۱۸۰۰ participants were enrolled in a cohort study in Shahrekord. Data were collected using a Food Frequency Questionnaire (FFQ). The potential renal acid load (PRAL) was calculated using the intestinal absorption of five nutrients including protein, potassium, phosphorus, magnesium, and calcium. The association of dietary acid load with NCDs was investigated in two models. Then, the raw model was adjusted by including calorie intake and age; after adjusting the effect of the two variables, the association between dietary acid load and the studied NCDs was not statistically significant. Results: The mean age of the participants was ۵۱.۴۹±۹.۲۷ years, and ۹۴۱ (۵۲.۲۷%) of them were female. Mean±SD acid load score was -۶.۸۸±۲۳.۲۳. The results showed that there was a significant association between dietary acid load and age (P=۰.۰۰۵), weight (P=۰.۰۰۰۱), waist circumference (P=۰.۰۱۶), hip circumference (P=۰.۰۰۰۱), waist-to-hip ratio (P=۰.۰۱), body mass index (P=۰.۰۰۴), and triglyceride (P=۰.۰۱۲). In the raw model, a significant association was observed between dietary acid load and hypertension (OR=۰.۵۷, ۰.۳۹-۰.۸). Conclusion: In this study, no significant association was observed between dietary acid load and NCDs, but the variable was associated with weight and body mass index as the most important risk factors for NCDs.

کلیدواژه ها:

Diet ، Dietary acid load ، Noncommunicable diseases ، Cohort studies ، Diabetes mellitus ، Hypertension ، Myocardial Infarction ، Stroke.