Prevalence and Pattern of GATA۳ Immunohistochemical Expression in Female Genital Tract Adenocarcinomas

Background & Objective: GATA۳ immunohistochemistry has been described as a highly sensitive marker in determining carcinomas of breast and urothelial origin. In the gynecologic system, it can be used as a marker to diagnose mesonephric or mesonephric-like carcinomas and trophoblastic tumors. The present study was performed to determine the diagnostic value of GATA۳ in gynecological adenocarcinomas.Methods: A total of ۱۸۷ samples from different types of endometrial, endocervical, and ovarian carcinomas were analyzed for intensity and percentage of GATA۳ expression in tumor cells. The relationship between GATA۳ expression and clinicopathological parameters was investigated.Results: A total of ۱۸۷ patients including ۱۰۱ ovarian, ۷۷ endometrial, and ۹ endocervical adenocarcinomas were investigated. Weak and focal expression of this marker was observed in ۵. ۱% (۴/۷۷) endometrial, ۱۲.۹% (۱۳/۱۰۱) ovarian, and ۱۱.۱% (۱/۹) endocervical adenocarcinomas. The mean H score in all subtypes was less than ۱۰.۶ (۲-۳۵). There was no statistically significant correlation between GATA۳ expression in tumor cells with clinical stage, and tumor recurrence or metastasis.Conclusion: GATA۳ is infrequently, weak, or focally expressed in most of the common gynecological adenocarcinomas.

کلیدواژه ها:

Adenocarcinoma ، Female genital tract ، GATA۳ ، Immunohistochemistry