The role of Staphylococcus aureus enterotoxin B in chronic rhinosinusitis with nasal polyposis
سال انتشار: 1402
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 58
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شناسه ملی سند علمی:
MEDISM24_453
تاریخ نمایه سازی: 6 اسفند 1402
چکیده مقاله:
CRS with nasal polyps (CRSwNP) is a multifactorial disease, and various etiological factors like bacterial superantigens are known to develop this disease. Recent studies reported that Staphylococcus aureus nasal colonization was detected in ۶۷% of the patients with CRSwNP. Moreover, it was reported that specific IgE against S. aureus enterotoxins are discovered in almost half of the nasal tissue homogenates from nasal polyps. Thus, investigations have highlighted the role of staphylococcal enterotoxins, especially enterotoxin B (SEB), in pathogenesis of CRSwNP.The destruction of mucosal integrity was reported as a main SEB-related pathogenic mechanisms in CRSwNP. SEB activates Toll Like Receptor ۲ and triggers the production of pro-inflammatory cytokines; furthermore, it induces reactive oxygen species and endoplasmic reticulum stress-induced inflammation that may cause epithelial cell integrity disruption and enhance their permeability. SEB-induced Type ۲/Th۲ pathway results in degranulation of eosinophils, cationic proteins production, and localized eosinophilic inflammation. Furthermore, SEB may be involved in the expression of RORC and HIF-۱α in Tregs and by maintaining the inflammation in sinonasal mucosa that could have a main role in the pathogenesis of nasal polyposis. Different in vitro findings were confirmed in animal studies; however, in vivo analysis of SEB-induced nasal polyps and CRS remains unfulfilled due to the lack of appropriate animal models. Finally, after elucidating different aspects of SEB pathogenesis in CRSwNP, therapeutic agents have been tested in recent studies with some encouraging results.CONCLUSIONThe purpose of this article is to summarize the most important findings regarding SEB-induced CRS and nasal polyposis.
کلیدواژه ها:
نویسندگان
Amin Khoshbayan
Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Zahra Chegini
Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Aref Shariati
Molecular and Medicine Research Center, Khomein University of Medical Sciences, Khomein, Iran